Highlights: (1) The normal gut microbiome is disrupted in patients who are critically ill. (2) 3-indoxyl sulfate is a gut bacteria byproduct that is excreted in the urine. (3) Evaluate urine 3-indoxyl sulfate as a gut-specific biomarker in the ICU population.
The oral and esophageal microbiomes are closely related within individuals, and esophageal microbiome alterations correlate with tissue gene expression changes.
In a large prospective cohort of liver transplantation (LT) recipients, we identify associations between colonization by multidrug-resistant bacteria (MDRB) and microbiome dysbiosis pre- and post-LT, suggesting colonizing MDRB as an important target for microbiome-informed therapeutic approaches post-LT.
Clinical interventions affecting iron status may alter biologically relevant microbial metabolites in the murine gut microbiome.
My postdoctoral research explored the dynamics between colonizing and infectious MDRO and commensal bacteria within the gut and oral microbiome. One main focus has been the study of the oral and gut microbiomes and mycobiomes in immunocompromised hosts, primarily liver transplant recipients and people living with HIV. Through 16S rRNA, ITS, and metagenomic sequencing, we linked clinically relevant patient outcomes with changes in the gut or oral micro- and myco-bial structure and diversity.
A fun ASM Microbe competition where speakers described their research using only the ten hundred most commonly used words in English
*Enterococcus* levels at ICU admission was associated with risk for death or all-cause infection
An introduction to basic concepts related to basic, clinical, and translational microbiome studies.