Increased CPE detection in patients with COVID-19 may signal a re-emergence of these highly resistant pathogens in the wake of the global pandemic. Increased surveillance and antimicrobial stewardship efforts will be needed to mitigate their future impact.
Through my postdoctoral research, I have explored genomic and evolutionary characteristics of multidrug-resistant organisms (MDRO), including major public health threats such as carbapenem-resistant Enterobacterales (CRE). I have experience developing, implementing, and analyzing Ion Torrent, Illumina, and Oxford Nanopore sequencing pipelines to study the evolutionary history of MDRO, genomic determinants of multidrug resistance, and transmission and spread of resistance via mobile genetic elements. A major focus has been liver transplant recipients and other immunocompromised hosts, in whom colonizing and infectious MDRO are a major contributor to morbidity and mortality.
MRSA strains adapt to the host airway environment by undergoing substantial bacterial metabolic reprogramming to promote biofilm production and limit the generation of oxidants.
In this mini review, we addressed recent advances in the molecular epidemiology of multidrug-resistant *E. cloacae* complex, focusing on the global expansion of CREC.
While REL reduced IMI MICs in a majority of diverse CRE isolates, including high-risk clones, chromosomal factors had an impact on IMI-REL susceptibilities and may contribute to elevated MICs.
The remarkable ability of *E. cloacae* complex to acquire and disseminate cross-class antibiotic resistance rather than virulence determinants, coupled with antibiotic pressure, likely led to the wide dissemination of CREC