*K. pneumoniae* ST258 elicits a disease-tolerant immune response and adapts to the host airway, enabling its global success
Increased CPE detection in patients with COVID-19 may signal a re-emergence of these highly resistant pathogens in the wake of the global pandemic. Increased surveillance and antimicrobial stewardship efforts will be needed to mitigate their future impact.
Highlights: (1) Mutations (SNPs) in crrB induce high-level polymyxin resistance and virulence; (2) CrrB SNPs mediate the addition of both L-Ara4N and pEtN to lipid A; (3) CrrB SNPs alter carbon metabolism including the pentose phosphate pathway; (4) These changes lead to an increase in bacterial virulence at a fitness cost