antimicrobial resistance

Population structure of blaKPC-harbouring IncN plasmids at a New York City medical centre and evidence for multi-species horizontal transmission

Host diversity within genetic clusters of blaKPC-harbouring IncN plasmids suggest frequent mobilization of discrete plasmid components.

Carbapenemase-producing Enterobacterales causing secondary infections during the COVID-19 crisis at a New York City hospital

Increased CPE detection in patients with COVID-19 may signal a re-emergence of these highly resistant pathogens in the wake of the global pandemic. Increased surveillance and antimicrobial stewardship efforts will be needed to mitigate their future impact.

CrrB Positively Regulates High-Level Polymyxin Resistance and Virulence in Klebsiella pneumoniae

Highlights: (1) Mutations (SNPs) in crrB induce high-level polymyxin resistance and virulence; (2) CrrB SNPs mediate the addition of both L-Ara4N and pEtN to lipid A; (3) CrrB SNPs alter carbon metabolism including the pentose phosphate pathway; (4) These changes lead to an increase in bacterial virulence at a fitness cost