Intestinal Dysbiosis and Risk of Posttransplant Clostridioides difficile Infection in a Longitudinal Cohort of Liver Transplant Recipients
Identification of clinical and microbiome factors to contribute to the development of Clostridium difficile in a cohort of patients …
Genomic and epidemiological features of two dominant methicillin-susceptible Staphylococcus aureus clones from a neonatal intensive care unit surveillance effort
Distinct genomic and epidemiological characteristics of dominating neonatal-colonizing MSSA clones ST398 and ST1898
Partial ORF1ab Gene Target Failure with Omicron BA.2.12.1
Partial ORF1ab gene target failure in clinical SARS-CoV-2 testing identifies BA.2.12.1 variant samples
Development and performance of a point-of-care rapid antigen test for detection of SARS-CoV-2 variants
Unique construction of a point-of-care rapid antigen test using two pairs of monoclonal antibodies has led to good performance that …
Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection
K. pneumoniae ST258 elicits a disease-tolerant immune response and adapts to the host airway, enabling its global success
Population structure of blaKPC-harbouring IncN plasmids at a New York City medical centre and evidence for multi-species horizontal transmission
Host diversity within genetic clusters of blaKPC-harbouring IncN plasmids suggest frequent mobilization of discrete plasmid components.
Oral Microbiome Alterations and SARS-CoV-2 Saliva Viral Load in Patients with COVID-19
Importance: Alterations to the saliva microbiome based on SARS-CoV-2 viral load indicate potential biologically relevant …
Prolonged severe acute respiratory syndrome coronavirus 2 persistence, attenuated immunologic response, and viral evolution in a solid organ transplant patient
SARS-CoV-2 viral persistence in a solid organ transplant recipient
Emergence and expansion of SARS-CoV-2 B.1.526 after identification in New York
We report the emergence of the SARS-CoV-2 variant lineage Iota (B.1.526) in New York City in early 2021
Spa Typing of Staphylococcus aureus in a Neonatal Intensive Care Unit During Routine Surveillance
An 18-month surveillance effort for S. aureus colonization in a neonatal ICU
An acquired acyltransferase promotes Klebsiella pneumoniae ST258 respiratory infection
Highlights: (1) An acyltransferase (atf3) is prevalent in ST258 K. pneumoniae; (2) Expression of atf3 enhances glycolysis, increasing …
Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation
S. aureus induces a distinct airway immunometabolic response dominated by the release of the electrophilic metabolite, itaconate, which …
The Brief Case: A Maggot Mystery-Ignatzschineria larvae Sepsis Secondary to an Infested Wound
This case represents the first conclusive documented human infection with I. larvae confirmed by whole-genome sequencing.
Time to act-assessing variations in qPCR analyses in biological nitrogen removal with examples from partial nitritation/anammox systems
Highlights: (1) Assessment of variation in qPCR analysis of biological nitrogen removal microbiome. (2) Comparison of qPCR results …
Associations between urinary 3-indoxyl sulfate, a gut microbiome-derived biomarker, and patient outcomes after intensive care unit admission
Highlights: (1) The normal gut microbiome is disrupted in patients who are critically ill. (2) 3-indoxyl sulfate is a gut bacteria …
Pre-test symptom duration and cycle threshold values for SARS-CoV-2 reverse transcription-PCR (RT-PCR) predict COVID-19 mortality
SARS-CoV-2 RT-PCR Ct value and duration of symptoms may be useful in risk stratification of patients with COVID-19.
Relationship of the Esophageal Microbiome and Tissue Gene Expression and Links to the Oral Microbiome: A Randomized Clinical Trial
The oral and esophageal microbiomes are closely related within individuals, and esophageal microbiome alterations correlate with tissue …
CrrB Positively Regulates High-Level Polymyxin Resistance and Virulence in Klebsiella pneumoniae
Highlights: (1) Mutations (SNPs) in crrB induce high-level polymyxin resistance and virulence; (2) CrrB SNPs mediate the addition of …
TAML- and Buffer-Catalyzed Oxidation of Picric Acid by H2O2: Products, Kinetics, DFT, and the Mechanism of Dual Catalysis
Studies of the oxidative degradation of picric acid (2,4,6-trinitrophenol) by H2O2 catalyzed by a fluorine-tailed tetraamido …
Subgingival microbiome and clinical periodontal status in an elderly cohort: The WHICAP ancillary study of oral health
Pertrubations in the subgingival microbiome in elderly individuals
Oral and gut microbial diversity and immune regulation in patients with HIV on antiretroviral therapy
Dysbiotic oral and gut microbiome in ART-treated PLWH with prevalent severe periodontitis
Colonizing multidrug-resistant bacteria and the longitudinal evolution of the intestinal microbiome after liver transplantation
In a large prospective cohort of liver transplantation (LT) recipients, we identify associations between colonization by …
Transfusional iron overload and intravenous iron infusions modify the mouse gut microbiota similarly to dietary iron
Clinical interventions affecting iron status may alter biologically relevant microbial metabolites in the murine gut microbiome.
Emergence of Polymyxin Resistance in Clinical Klebsiella pneumoniae Through Diverse Genetic Adaptations: A Genomic, Retrospective Cohort Study
A genomic survey of clinical polymyxin-resistant (PR) K. pneumoniae reveals remarkably heterogenous molecular mechanisms leading to PR.
Escherichia coli harboring mcr-1 in a cluster of liver transplant recipients: Detection through active surveillance and whole-genome sequencing
We report detection of mcr-1-carrying Escherichia coli ST117 in a cluster of three liver transplant recipients.
Metabolic adaptation in MRSA pneumonia
MRSA strains adapt to the host airway environment by undergoing substantial bacterial metabolic reprogramming to promote biofilm …
Multidrug-resistant Enterobacter cloacae complex emerging as a global, diversifying threat
In this mini review, we addressed recent advances in the molecular epidemiology of multidrug-resistant E. cloacae complex, focusing on …
Metatranscriptomic investigation of adaptation in NO and N2O production from a lab-scale nitrification process upon repeated exposure to anoxic–aerobic cycling
This study identified underlying metabolic processes and mechanisms contributing to NO and N2O production in a lab-scale BNR process
Structural and functional interrogation of selected biological nitrogen removal systems in the United States, Denmark, and Singapore using shotgun metagenomics
Metagenomics revealed that inoculation and operating conditions of engineered bioprocesses shape the resident microbial structure and …
Pathogen colonization of the gastrointestinal microbiome at intensive care unit admission and risk for subsequent death or infection
Enterococcus levels at ICU admission was associated with risk for death or all-cause infection
Clonal background, resistance gene profile, and porin gene mutations modulate in vitro susceptibility to imipenem-relebactam in diverse Enterobacteriaceae
While REL reduced IMI MICs in a majority of diverse CRE isolates, including high-risk clones, chromosomal factors had an impact on …
Genomic and geographic context for the evolution of high-risk carbapenem-resistant Enterobacter cloacae complex clones ST171 and ST78
The remarkable ability of E. cloacae complex to acquire and disseminate cross-class antibiotic resistance rather than virulence …
Successive emergence of ceftazidime-avibactam resistance through distinct genomic adaptations in blaKPC-2-harboring Klebsiella pneumoniae sequence type 307 isolates
Multiple genomic adaptations were linked to emergent CAZ-AVI- and MEM-resistance in blaKPC-2-harboring K. pneumoniae ST307.
Comammox functionality identified in diverse engineered biological wastewater treatment
A metagenomic survey was conducted to quantify contributions of comammox bacteria to overall nitrogen cycling in BNR processes.
Experimental and theoretical evidence for multiple FeIV reactive intermediates in TAML-activator catalysis: Rationalizing a counterintuitive reactivity order
In the first in-depth study of the reactivity of the oxidized TAML species, the non-monotonic reactivity pattern could be explained by …
